Robert Neville (Will Smith, Men in Black) is a brilliant scientist. But when a man-made virus can’t be contained, Neville finds himself the last human survivor in New York City and potentially the world. For three years he faithfully sends out daily radio messages, desperate to find other survivors. But he is not alone Mutant victims of the plague (The Infected) lurk in the shadows, waiting to catch Neville out. As perhaps Earth’s last hope for mankind, Neville is driven only by the desire to somehow reverse the effects of the virus before it’s too late.